Managing Superwarfarin Poisoning: A Challenging Case


Rev Med Chil. 2023 Jun;151(6):797-800. doi: 10.4067/s0034-98872023000600797.


Human intoxication by long-acting anticoagulant rodenticides, known as superwarfarins, causes coagulopathy that is difficult to manage. We present the case of a 42-year-old man who ingested a toxic dose of rodenticide in a suicide attempt, evolving with epistaxis, INR of 11.6, and needing hospitalization. For seven days, serial controls of coagulation tests were carried out, with optimization of different doses of Vitamin K supplementation. The case highlights this type of anticoagulant’s potency and prolonged half-life (approximately six weeks), which requires regular clinical control and satisfactory treatment adherence.

PMID:38801389 | DOI:10.4067/s0034-98872023000600797