New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03

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Chin J Nat Med. 2024 Apr;22(4):356-364. doi: 10.1016/S1875-5364(24)60629-1.

ABSTRACT

A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1-11), including seven novel compounds designated arthrinoids A-G (1-7). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL-1.

PMID:38658098 | DOI:10.1016/S1875-5364(24)60629-1