Nitidane: An Irregular Prenylated Diterpene from the Cuticle of the Springtail Heteromurus nitidus

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J Nat Prod. 2024 Apr 26. doi: 10.1021/acs.jnatprod.4c00258. Online ahead of print.

ABSTRACT

Collembola are closely related to insects, but our knowledge of their often unique chemistry is limited. Here we report the identification of the epicuticular lipid nitidane, representing a novel class of epicuticular lipids. Nitidane (4) is an irregular terpene consisting of seven isoprene units, made up of a diterpene core that is modified by a geranyl moiety that is itself prenylated. The observed [46+(22+11)1]-terpene structure has not been reported before.

PMID:38668715 | DOI:10.1021/acs.jnatprod.4c00258