The effects of ursolic acid on cardiometabolic risk factors: a systematic review and meta-analysis

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Future Cardiol. 2024;20(3):151-161. doi: 10.1080/14796678.2024.2349476. Epub 2024 May 29.

ABSTRACT

Aim: Ursolic acid (UA) has an important biological role in the fight against fat accumulation, insulin resistance, obesity and inflammation. Therefore, in the current review and meta-analysis work, we investigate the effects of UA (dosage range is 50.94 to 450 mg/day) on cardiometabolic risk factors. Materials & methods: After searching the studies up to February 2023, six articles were included in the study. Results: The pooled effect size showed that UA supplementation didn’t significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglyceride and high-density lipoprotein compared with control groups. Conclusion: UA supplementation had no significant effect on the cardiometabolic risk factors in adults.

PMID:38923885 | DOI:10.1080/14796678.2024.2349476