Chemical composition and anti-angiogenic activity of the essential oil from Blumea eriantha D.C

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Nat Prod Res. 2024 Jun;38(11):1918-1923. doi: 10.1080/14786419.2023.2227990. Epub 2023 Jun 25.

ABSTRACT

Blumea eriantha D.C is a weed from Asteraceae family and is reported to have anticancer activity. The essential oil from the aerial parts was extracted by steam distillation method with the yield of 0.36%. Through GC-MS analysis of the oil, seventeen compounds could be identified by comparing with linear retention indices with the library. Out of the seventeen compounds β-Caryophylline oxide was isolated by column chromatography with gradient elution and the structure was determined through FT-IR, MS, 1HNMR, 13 C NMR and DEPT. The oil was evaluated for its effect on angiogenesis using Chorioallantoic Membrane Assay (CAM Assay). The concentration dependent antiangiogenic effect was observed with IC 50 value of 19.28 ppm.

PMID:38739564 | DOI:10.1080/14786419.2023.2227990